Dr. Tanzi is the Joseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation and Massachusetts General Hospital. Dr. Tanzi’s main focus is on identifying and characterizing Alzheimer’s disease associated gene mutations and variants with the ultimate goal of defining the molecular, cellular, and biochemical events leading to neuronal death in the brains of Alzheimer’s disease patients. Dr. Tanzi’s lab has been involved in the discovery of three of the four genes implicated in playing a role in familial Alzheimer’s disease. Dr. Tanzi has focused his research on determining the pathogenic mechanisms by which defects in these genes contribute to the neurodegenerative process in the brains of patients with Alzheimer’s disease. With the use of cell and animal models, Dr. Tanzi is gaining an in-depth understanding of the normal function of the Alzheimer’s disease genes and how mutations and variants of these genes can lead to amyloid deposition, neuronal death, and dementia. This research has a direct impact of the development of an effective treatment for Alzheimer’s disease and Dr. Tanzi’s work is key to the pathways that AZTherapies is pursuing.
See more at: http://madrc.mgh.harvard.edu/members/10924